Table 5.
Repertoire of Jak kinuses signal transducer and activator of transcription, and negative regulatory genes
| Gene name | Abbr | Unigene | NCBI | KEGG | TO-VS-SAV3 | TO-VS- IFN/SAV3 | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Log2 (Fold change) | Reg | P-value | Log2(Fold Change) | Reg | P-value | |||||
| A: Jaks | ||||||||||
| Tyrosine-protein kinase JAK1 | JAK1 | CL2001.7 | NP_571148 | K11217 | 1.17 | Up | 1.87e-185 | 2.61 | Up | 1.01e-05 |
| Janus kinase 2 | JAK2 | Unig38863 | ACU12481 | K04447 | -1.97 | Down | 3.84e-05 | |||
| Tyrosine kinase 2 | TyK2 | Unig6068 | ACU12483.1 | K11219 | -1.07 | Down | 7.70e-27 | |||
| B: Signal transducers | ||||||||||
| Signal transducer and activator of transcription 1 | STAT1 | CL2066.1 | NP_001134757.1 | K11220 | 6.03 | Up | 3.06e-68 | 7.11 | Up | 1.20e-4 |
| Signal transducer and activator of transcription 2 | STAT2 | Unig6362 | NP_001138896.1 | K11221 | 1.88 | Up | 1.31e-06 | 2.67 | Up | 1.10e-4 |
| Signal transducer and activator of transcription 3 | STAT3 | CL10061.2 | GU933429.1 | K04692 | -1.32 | Down | 4.00e-05 | |||
| Signal transducer and activator of transcription 5B | STAT5 | Unig39041 | XP_003454096.1 | K11224 | -2.32 | Down | 3.00e-05 | |||
| Signal transducer and activator of transcription 6 | STAT6 | Unig2573 | ACU12488.1 | K11225 | 1.29 | Up | 3.83e-57 | |||
| C: Negative loop feedback | ||||||||||
| Suppressor of cytokine signaling 3 | SOCS3 | Unig14487 | NP_001139640.1 | K04696 | -1.25 | Down | 1.02e-07 | 1.89 | Up | 1.04e-07 |
| Suppressor of cytokine signaling 1 | SOCS1 | Unig8629 | CCC15083.1 | K04694 | 6.86 | Up | 1.31e-207 | 7.78 | Up | 1.11e-04 |
| E3 SUMO-protein ligase PIAS2 | PIAS2 | Unig18900 | XP_003457088.1 | K16063 | -1.06 | Down | 2.00e-05 | 1.01 | Up | 7.71e-07 |