Table 6.
Apoptosis and cell proliferation target genes
| Gene name | Abbr | Unigenes | NCBI | KEGG | TO-VS-SAV3 | TO-VS-IFN/SAV3 | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Log2 (Fold change) | Reg | P-value | Log2 (Fold change) | Reg | P-value | |||||
| A: Stat pathway genes | ||||||||||
| Signal transducing adaptor molecule 2 | STAM2 | CL86.2 | NP_001007370.1 | K04705 | -1.51 | Down | 1.76e-12 | |||
| Interferon regulatory factor 9 | IRF9 | CL11337.2 | NP_001167190.1 | K04693 | 1.65 | Up | 1.26e-13 | |||
| CREB binding protein | CBP | CL7696.2 | AAY85296.1 | K04498 | -2.67 | Down | 1.14e-06 | |||
| Threonine-protein kinase pim-1-like | Pim-1 | CL9459.2 | XP_003449193.1 | K04702 | -1.11 | Down | 2.38e-55 | 1.07 | Up | 5.80e-90 |
| Threonine-protein kinase pim-3-like | Pim-3 | CL1163.1 | XP_003445092.1 | K08807 | -1.63 | Down | 9.75e-179 | |||
| B: MAPK Signaling pathway | ||||||||||
| Protein tyrosine phosphatase, non-receptor 11 | PTPN11 | Unig19725 | XP_003965393.1 | K07293 | -2.25 | Down | 2.21e-3 | |||
| Son of sevenless homolog 1 | SOS1 | CL9403.1 | XP_003216158.1 | K03099 | -2.66 | Down | 3.28e-10 | -1.06 | Down | 1.17e-3 |
| Son of sevenless homolog 2 | SOS2 | Unig28623 | XP_003443018.1 | K03099 | -2.57 | Down | 5.88e-07 | |||
| Transcriptional regulator Myc-2 | Myc-2 | Unig13199 | NP_001167287.1 | K04377 | -2.16 | Down | 3.244e-07 | 1.11 | Up | 1.03e-05 |
| G1/S-specific cyclin-D1 | CycD1 | CL11123.1 | NP_001158863.1 | K04503 | -1.33 | Down | 3.33e-05 | |||
| G1/S-specific cyclin-D2 | CycD2 | CL3895.1 | ACO14329.1 | K10151 | -2.23 | Down | 1.35e-168 | |||
| Apoptosis regulator Bcl-X | BcIXL | CL2019.1 | ACI68003.1 | K04070 | -1.30 | Down | 1.21e-38 | |||
| Sprouty-related, EVH1 domain containing | Sprouty | CL10970.1 | XP_003456564.1 | K04703 | -1.84 | Down | 7.73e-62 | |||
| C: PI3K-AKT pathway | ||||||||||
| Akt RAC-beta serine/threonine-protein kinase | AKT | CL4020.1 | ACY30363.1 | K04456 | -1.59 | Down | 3.83e-16 | |||
| Phosphatidylinositol-4,5-bisphosphate 3-kinase | PIK3CA | Unig30697 | NP_998471.1 | K00922 | -1.64 | Down | 2.0e-5 | -1.21 | Down | 4.84e-3 |
| D: Other genes | ||||||||||
| E3 ubiquitin-protein ligase CBL-B | CBL-B | Unig24091 | XP_001921961.3 | K04707 | 1.80 | Up | 3.48e-07 | |||