Table 5.
Efficacy of Balloon Kyphoplasty for Malignant Spinal Fractures: Results of a Meta-Analysis
| Variable | No. of Studies | No. of Patients or Levels | Size of Effect | 95% CI | P | I2 (%) |
|---|---|---|---|---|---|---|
| Pain: VAS score (0-10) | ||||||
| Basal (postoperative) | 469–72 | 172 patients | SMD: 3.85 | 2.99 to 4.71 | < .001 | 79 |
| Baseline (end of follow-up) | 370–72 | 109 patients | SMD: 4.27 | 2.38 to 6.21 | < .001 | 93 |
| Functional capacity: ODI (0-100) | ||||||
| Baseline (postoperative) | 469,71,72 | 173 patients | WMD: −28.78 | −11.5 to −46.0 | .001 | 99 |
| Baseline (< 6 months) | 269,73 | 82 patients | WMD: −16.39 | −14.25 to −18.5 | .001 | 0 |
| Baseline (2 years) | 271,72 | 91 patients | WMD: −41.95 | −39.42 to −44.5 | .001 | 0 |
| Kyphotic deformity: Cobb angle | ||||||
| Basal (postoperative) | 371,72,74 | 180 levels | SMD: −0.69 | −0.20 to −1.16 | .001 | 78 |
| Baseline (end of follow-up) | 371,72,74 | 155 levels | SMD: −0.39 | 0.05 to −0.84 | .08 | 74 |
| Vertebral height | 369,70,74 | 342 levels | RR: 47% | 33% to 61% | 38 | |
| Percentage of restitution increase, mm | 271,72 | 158 levels | ||||
| Anterior vertebral body | ||||||
| Basal (postoperative) | SMD: 0.28 | 0.06 to 0.51 | .01 | 0 | ||
| Baseline (end of follow-up) | SMD: 0.15 | −0.16 to 0.45 | .35 | 37 | ||
| Midline vertebral body | ||||||
| Basal (postoperative) | SMD: 0.28 | 0.003 to 0.56 | .04 | 34 | ||
| Baseline (end of follow-up) | SMD: 0.15 | −0.17 to 0.46 | .35 | 41 |
NOTE. All based on random effects meta-analysis. Reprinted with permission.68
Abbreviations: ODI, Oswestry Disability Index; RR, rate ratio; SMD, standardized mean difference; VAS, visual analogue scale; WMD, weighted mean difference.