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. 2016 May 23;213(4):479–494. doi: 10.1083/jcb.201510065

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© 2016 Cummings et al.

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Figure 9. — Functional NC1 domains control collagen IV protomer and network assembly. (A) Collagen IV NC1 domains nucleate protomer assembly by controlling chain stoichiometry, specificity, and registration. (B) Extracellular Cl⁻ concentrations signal protomers to oligomerize into networks, forming NC1 hexamers at the protomer–protomer junctions. At the NC1 junctions, hexamers are reinforced with sulfilimine cross-links by PXDN and Br⁻. (C) Assembled collagen IV networks function as a scaffold for binding other macromolecules and growth factors in BMs.