Table 2.

Gene–Drug Knowledge Bases to Assist in Clinical Interpretation of Tumor Variants

Knowledge Base	Description	Types of Relationships	Clinical Domains
Pharmacogenomics Knowledge Base (PharmGKB)85	Contains annotations on genetic variants and gene–drug–disease relationships via literature reviews	Gene–drug, germline variant–drug–host response	Somatic and germline pharmacogenomics
DrugBank72	A compilation of detailed drug data with comprehensive drug target information	Gene–drug, drug–pathway	Somatic and germline pharmacogenomics
STITCH86	An interaction network of genes, drugs, and proteins	Gene–drug, gene–chemical	Somatic and germline pharmacogenomics
Therapeutic Target Database (TTD)87	A database of known and explored therapeutic drug targets, the targeted disease, pathway information, and the associated drugs	Gene–drug, drug–pathway, drug–target	Somatic and germline pharmacogenomics