Table 1.
The clinical and biochemical characteristics of the male IHH patients and matched healthy controls
| Characteristics | Male IHH patients (n = 75) | Healthy controls (n = 135) | Statistical values | P |
|---|---|---|---|---|
| Age (years) | 21.4 ± 3.7 | 21.1 ± 3.4 | 0.65* | 0.487 |
| BMI (kg/m2) | 23.66 ± 5.49 | 21.72 ± 3.94 | 2.98* | 0.008 |
| SBP (mmHg) | 118.79 ± 11.83 | 116.77 ± 12.76 | 1.19* | 0.262 |
| DBP (mmHg) | 71.09 ± 8.86 | 74.21 ± 8.07 | −2.62* | 0.011 |
| T (nmol/L) | 0.95 (0.57–1.81) | 18.32 (14.90–22.17) | 20.00† | <0.001 |
| LH (mU/ml) | 0.21 (0.02–0.81) | 3.51 (2.89–4.44) | 759.00† | <0.001 |
| FSH (U/L) | 0.93 (0.47–1.60) | 3.98 (2.91–5.14) | 1077.50† | <0.001 |
| FBG (mmol/L) | 4.66 ± 0.45 | 4.37 ± 0.99 | 2.17* | 0.031 |
| TG (mmol/L) | 1.32 ± 0.72 | 0.69 ± 0.31 | 7.87* | <0.001 |
| TC (mmol/L) | 3.98 ± 0.69 | 3.66 ± 0.64 | 2.94* | 0.004 |
| HDL-C (mmol/L) | 1.17 ± 0.28 | 1.32 ± 0.33 | −2.65* | 0.003 |
| LDL-C (mmol/L) | 2.38 ± 0.65 | 2.03 ± 0.54 | 3.68* | 0.001 |
| ALT (U/L) | 25.89 ± 20.60 | 17.14 ± 6.00 | 4.21* | 0.003 |
| AST (U/L) | 20.35 ± 8.77 | 17.37 ± 3.11 | 2.20* | 0.022 |
| GGT (U/L) | 19.87 ± 8.93 | 17.98 ± 8.73 | 1.30* | 0.094 |
| Cr (U/L) | 61.85 ± 8.70 | 71.85 ± 8.65 | −7.04* | <0.001 |
| ACTH (pmol/L) | 8.25 ± 3.78 | 6.97 ± 2.81 | 3.04* | 0.017 |
| Cortisol (nmol/L) | 366.70 ± 142.48 | 452.82 ± 141.53 | −0.88* | <0.001 |
| With NAFLD | 22 (34.9)‡ | 6 (4.4) | – | <0.001 |
Data are shown as mean ± SD, median (interquartile range), or n (%).*t values; †U values. ‡Among 75 male IHH patients, 63 patients were undergoing abdominal ultrasonography. IHH: Idiopathic hypogonadotropic hypogonadism; BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; T: Serum testosterone; LH: Serum luteinizing hormone; FSH: Serum follicle-stimulating hormone; FBG: Fasting blood glucose; TC: Total cholesterol; TG: Triglycerides; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transpeptidase; Cr: Serum creatinine; ACTH: Adrenocorticotropic hormone; NAFLD: Nonalcoholic fatty liver disease; SD: Standard deviation.