Table 2.
The clinical and biochemical characteristics of the 63 IHH patients with and without NAFLD
| Characteristics | NAFLD group (n = 22) | Non-NAFLD group (n = 41) | t | P |
|---|---|---|---|---|
| Age (years) | 22.91 ± 4.73 | 20.66 ± 2.89 | −2.34 | 0.051 |
| BMI (kg/m2) | 28.73 ± 5.42 | 20.57 ± 3.58 | −7.18 | <0.001 |
| SBP (mmHg) | 123.41 ± 10.70 | 116.10 ± 10.74 | −2.58 | 0.012 |
| DBP (mmHg) | 74.50 ± 9.53 | 68.24 ± 7.42 | −2.88 | 0.005 |
| FBG (mmol/L) | 4.68 ± 0.53 | 4.62 ± 0.43 | −0.76 | 0.625 |
| TG (mmol/L) | 1.59 ± 0.68 | 1.06 ± 0.64 | −2.58 | 0.013 |
| TC (mmol/L) | 4.33 ± 0.74 | 3.76 ± 0.60 | −2.80 | 0.007 |
| HDL-C (mmol/L) | 1.07 ± 0.28 | 1.22 ± 0.20 | 2.20 | 0.033 |
| LDL-C (mmol/L) | 2.64 ± 0.62 | 2.16 ± 0.61 | −2.57 | 0.013 |
| ALT (U/L) | 29.15 ± 14.40 | 22.85 ± 23.59 | −1.00 | 0.031 |
| AST (U/L) | 21.33 ± 10.51 | 19.52 ± 8.22 | −2.23 | 0.069 |
| GGT (U/L) | 24.49 ± 11.41 | 16.08 ± 6.82 | −7.98 | <0.001 |
| Cr (U/L) | 62.01 ± 7.31 | 61.05 ± 8.59 | −0.39 | 0.696 |
| ACTH (pmol/L) | 9.91 ± 4.98 | 7.60 ± 2.96 | −2.21 | 0.026 |
| Cortisol (nmol/L) | 349.43 ± 166.08 | 376.06 ± 146.47 | 3.58 | 0.553 |
| DHEAS (µg/L)* | 2123.7 ± 925.8 | 1417.1 ± 498.4 | −2.40 | 0.020 |
Data are shown as mean ± SD. *Among 63 patients who underwent abdominal ultrasonography, 39 subjects had records for DHEAS levels (11 in NAFLD group and 28 in non-NAFLD group). IHH: Idiopathic hypogonadotropic hypogonadism; NAFLD: Nonalcoholic fatty liver disease; BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; FBG: Fasting blood glucose; TC: Total cholesterol; TG: Triglycerides; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transpeptidase; Cr: Serum creatinine; ACTH: Adrenocorticotropic hormone; DHEAS: Dehydroepiandrosterone sulfate; SD: Standard deviation.