Table 2.
Trends in vitro susceptibilities to clotrimazole, fluconazole, miconazole, itraconazole, and nystatin among Candida albicans over an 8-year period
| Years | Isolates number | Clotrimazole, n (%) | Fluconazole, n (%) | Miconazole, n (%) | Itraconazole, n (%) | Nystatin, n (%) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tested number | S | SDD | R | Tested number | S | SDD | R | Tested number | S | SDD | R | Tested number | S | SDD | R | Tested number | S | SDD | R | ||
| 2006 | 42 | 42 | 41 (97.6) | 1 (2.4) | 0 (0) | 42 | 37 (88.1) | 4 (9.5) | 1 (2.4) | 42 | 24 (57.1) | 17 (40.5) | 1 (2.4) | 42 | 32 (76.2) | 7 (16.7) | 3 (7.1) | 42 | 36 (85.7) | 6 (14.3) | 0 (0) |
| 2007 | 126 | 126 | 125 (99.2) | 1 (0.8) | 0 (0) | 126 | 119 (94.4) | 6 (4.8) | 1 (0.8) | 110 | 56 (50.9) | 6 (5.5) | 48 (43.6) | 92 | 58 (63.0) | 3 (3.3) | 31 (33.7) | 126 | 126 (100.0) | 0 (0) | 0 (0) |
| 2008 | 219 | 199 | 182 (91.5) | 12 (6.0) | 5 (2.5) | 219 | 179 (81.7) | 29 (13.2) | 11 (5.0) | 219 | 97 (44.3) | 7 (3.2) | 115 (52.5) | 208 | 97 (46.6) | 2 (1.0) | 109 (52.4) | 219 | 217 (99.1) | 0 (0) | 2 (0.9) |
| 2009 | 223 | 221 | 197 (89.1) | 22 (10.0) | 2 (0.9) | 221 | 185 (83.7) | 27 (12.2) | 9 (4.1) | 221 | 97 (43.9) | 6 (2.7) | 118 (53.4) | 221 | 106 (48.0) | 0 (0) | 115 (52.0) | 218 | 216 (99.1) | 2 (0.9) | 0 (0) |
| 2010 | 289 | 245 | 219 (89.4) | 10 (4.1) | 16 (6.5) | 288 | 149 (51.7) | 19 (6.6) | 120 (41.7) | 288 | 109 (37.8) | 12 (4.2) | 167 (58.0) | 288 | 136 (47.2) | 2 (0.7) | 150 (52.1) | 288 | 288 (100.0) | 0 (0) | 0 (0) |
| 2011 | 257 | 256 | 240 (93.8) | 13 (5.1) | 3 (1.2) | 256 | 200 (78.1) | 36 (14.1) | 20 (7.8) | 256 | 97 (37.9) | 24 (9.4) | 135 (52.7) | 256 | 120 (46.9) | 4 (1.6) | 132 (51.6) | 256 | 256 (100.0) | 0 (0) | 0 (0) |
| 2012 | 213 | 212 | 195 (92.0) | 15 (7.1) | 2 (0.9) | 157 | 61 (38.9) | 9 (5.7) | 87 (55.4) | 210 | 81 (38.6) | 10 (4.8) | 119 (56.7) | 197 | 87 (44.2) | 7 (3.6) | 103 (52.3) | 212 | 211 (99.5) | 0 (0) | 1 (0.5) |
| 2013 | 406 | 405 | 358 (88.4) | 22 (5.4) | 25 (6.2) | 405 | 284 (70.1) | 85 (21.0) | 36 (8.9) | 405 | 143 (35.3) | 20 (4.9) | 242 (59.8) | 387 | 151 (39.0) | 8 (2.1) | 228 (58.9) | 405 | 405 (100.0) | 0 (0) | 0 (0) |
| Total | 1775 | 1706 | 1557 (91.3) | 96 (5.6) | 53 (3.1) | 1714 | 1214 (70.8) | 215 (12.5) | 285 (16.6) | 1751 | 704 (40.2) | 102 (5.8) | 945 (54.0) | 1691 | 787 (46.5) | 33 (2.0) | 871 (51.5) | 1766 | 1755 (99.4) | 8 (0.5) | 3 (0.2) |
R: Resistant; S: Susceptible; SDD: Susceptible-dose dependent.