Table 4.
Single and combined diagnostic parameters of T-SPOT.TB on SFMCs and PBMCs
| T-SPOT.TB on | 95% CI | |||||
|---|---|---|---|---|---|---|
| Sensitivity | Specificity | PPV | NPV | LR+ | LR− | |
| SFMC | 0.83 (0.36–0.99) | 0.86 (0.56–0.97) | 0.71 (0.30–0.95) | 0.92 (0.62–0.99) | 5.80 (1.54–22.10) | 0.19 (0.03–1.19) |
| PBMC | 0.67 (0.24–0.94) | 0.69 (0.39–0.90) | 0.50 (0.15–0.83) | 0.82 (0.48–0.97) | 2.17 (0.80–5.84) | 0.48 (0.15–1.60) |
| PBMC or SFMC (parallel) | 0.83 (0.36–0.99) | 0.62 (0.32–0.85) | 0.50 (0.20–0.80) | 0.89 (0.51–0.99) | 2.17 (1.00–4.70) | 0.27 (0.04–1.78) |
| PBMC and SFMC (serial) | 0.67 (0.24–0.94) | 0.93 (0.64–1.00) | 0.80 (0.30–0.99) | 0.87 (0.58–0.98) | 9.33 (1.30–67.03) | 0.36 (0.11–1.13) |
PPV: Positive predictive value; NPV: Negative predictive value; LR+: Likelihood ratio positive; LR−: Likelihood ratio negative; SFMCs: Synovial fluid mononuclear cells; PBMCs: Peripheral blood mononuclear cells; TB: Tuberculosis; CI: Confidence interval.