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Greatly increased mapping resolution in the HMDP as compared with a traditional cross between two inbred strains. Shown is the mapping of a strong cis-eQTL, for the gene Cyp2c37, by linkage in an F2 cross (blue line) or by association in the HMDP (black dots). The position of the gene is indicated by the red box. The F2 cross included about 300 mice and global transcript levels were determined using microarrays. The figure is reprinted from (44), with permission.
