Fig. 7.

Gene-by-environment interactions in response to a high-fat high-sucrose (HF/HS) diet. Shown are adipose transcript levels for two genes, sorbitol dehydrogenase (A) and histone deacetylase 1 (B), in mice fed either the chow diet (black dots) or the HF/HS diet (colored dots). The strains are rank ordered by transcript levels on the chow diet and the transcript levels on the HF/HS diet are colored according to the genotype of the peak cis-eQTL. In the case of sorbitol dehydrogenase, gene expression levels in mice with allele B are repressed by the diet, whereas those with allele A are induced. In the case of histone deacetylase 1, the induction is much larger in mice with genotype A than genotype B.