TABLE 1.
Clinical and molecular phenotypes studied in the HMDP resource
| Trait | Diet |
| Plasma lipids | C, HF, ATH |
| Adiposity | C, HF, ATH |
| Osteoporosis | C |
| Blood cell levels | C, HF, ATH |
| IR | C, HF, ATH |
| Fatty liver disease | HF, ATH |
| Heart failure induced by isoproterenol | ISO |
| Atherosclerosis | ATH |
| Diabetic nephropathy | C |
| Transcript levels | |
| Liver | C, HF, ATH |
| Adipose | C, HF |
| Aorta | ATH |
| Hippocampus | C |
| Striatum | C |
| Skeletal muscle | HF |
| Heart | C, ISO |
| Protein levels, liver | C |
| Metabolites | |
| Liver | C |
| Plasma | HF, ATH |
| Gut microbiome | C, HF ATH |
| DNA methylation | C |
Mice were maintained on chow (C), high-fat (HF), or atherogenic (ATH) diets or treated with ISO.