TABLE 3.

Concordance of human and mouse NAFLD GWAS genes

Gene	r	P	cis-eQTL	Tissue
Gckr	0.19	0.04	NS	Liver
Ncan	0.37	6 × 10−5	3 × 10−8	Adipose
Tm6 sf2	−0.23	0.01	NS	Adipose
Lyplal1	0.27	0.003	2 × 10−30	Liver
Trib1	0.24	0.012	NS	Adipose
Pnpla3	0.08	0.424	NS	Liver

Six genes, listed here, have been associated with NAFLD in human studies. Transcript levels for these genes were determined in livers and gonadal adipose tissue of the HMDP. Five of the six (the exception being Pnpla3) exhibited significant correlation (r) with hepatic TG levels in mice fed a high-fat high-carbohydrate diet in either liver or adipose. Two of the five had strong cis-eQTLs in liver (44).