Figure 5.

Anti-donor IgM or IgG antibody levels in recipients after islet Tx into the GSMS. To evaluate the sensitization to donor antigens, anti-donor IgM (left panels) and IgG (right panels) antibody levels were determined before, 2 weeks and 4 weeks after transplantation, except when recipient animals (Pig 3780, Pig 3777) were euthanized prior to 4 weeks due to pulmonary infection. Serum was tested at 3 weeks for these animals. IgM antibody levels were slightly elevated, but the level returned to the pre-transplant level in Pig 3780 (Group1A) (A). In contrast, there was no increase in IgM or IgG antibodies in Group1B (B) or Group2 pigs (C).