Figure 4.

Model-based clustering of high glucose response and oscillations. All scatter-plots are of the same two features, though colored according to suggested clusters for drift-corrected (top row) and raw (bottom row) versions of the data. Gaussian mixture model BICs suggest optimal clustering of 3 major cell sub-types: non-responders (blue), oscillating responders (red) and non-oscillating responders (green). Drift-corrected BIC for four clusters was similar to that for three clusters, it did not suggest the same clustering pattern as the raw data. Three clusters therefore robustly describe the cell sub-type number. The drift-corrected 3-cluster plot highlighted is provided in the Trace Cluster software app (Supplementary Software), where users can upload their own data for analysis.