Fig. 2. : anatomopathological findings on brain tissues samples stained with H&E. (A) Histological section of brain tissue samples of case 2 with a mildly affected white matter region revealing diffuse microglial hyperplasia, gliosis with reactive astrocytes and microdeposits of calcium (arrow). (B) Histological section of a brain tissue sample from case 3 with a mildly affected white matter region containing microglial nodules (arrow) and neuronophagia (dashed arrow). (C) Histological section of a brain tissue sample from case 4 with a more severely affected white matter region, revealing extensive destruction and infiltration by mononuclear inflammatory cells. Diffuse microglial hyperplasia was also present. In addition, severe gliosis with reactive gemistocytic astrocytes were diffusely distributed. (D) Histological section of a brain tissue sample from case 4 with a more severely affected white matter region showing extensive perivascular cuffing by lymphocytes (arrow). In addition, moderate gliosis with reactive gemistocytic astrocytes (dashed arrow) were diffusely distributed.