Table 2.
Details of the statistical analysis
| Compared subgroups of patients | Number of upregulated genes/downregulated genes (FC >2, uncorrected p) |
Number of statistically significant genes (corrected p) |
Names of the statistically significant genes |
RQ-PCR validation |
| Older (>55 y) versus younger (<55 y) |
379 / 316 | 3 |
ESPNL (FC = 2.2; p = 0.047) XLOC_007536 (FC = 2.08; p = 0.047) USP27X-AS1 (FC = 2.03; p = 0.047) |
Not analyzed |
| Good/acceptable cognitive status versus severe cognitive disability |
31 / 59 | 0 | – | Not analyzed |
| Institutionalized versus day-care center |
34 / 82 | 0 | – | Not analyzed |
| Older (>55 y) with good/acceptable cognitive status versus younger (<55 y) with severe intellectual disability |
1376 / 794 | 1 |
MTRNR2L12 (FC = 17.76; p = 0.00026) |
ΔΔCt = −5.36 FC = 41, p < 0.0001 |
| Older (>55 y) with good/acceptable cognitive status versus younger (<55 y) with cognitive deterioration |
971 / 1301 | 1 |
MTRNR2L12 (FC = 18.66; p = 0.00024) |
ΔΔCt = −5.16 FC = 35.7 p < 0.0001 |