Fig.2.

Recognition memory function in SAMP8 mice assessed in a novel object recognition (NOR) test. NOR performance in 10-month-old vehicle-dosed or liraglutide-treated SAMP8 mice. Vehicle-dosed 50% backcrossed SAMP8 mice and untreated 4-month-old SAMP8 control mice, respectively, served as controls for normal memory function. Vehicle-dosed 10-month-old SAMP8 mice showed poor object recognition memory performance, as compared to untreated 4-month-old SAMP8 mice. Liraglutide-treated 10-month-old SAMP8 mice did not show significant improvement of memory performance in the NOR test. The discrimination index was defined as the amount of time exploring the familiar object or the novel object over the total time spent exploring both objects multiplied by 100.  ^*p <  0.05 (one-way ANOVA, Dunnet’s post-hoc test).