Table 3.
Specific oxygen consumption of AQP1-KO and WT mice under 40 ng/g/min dobutamine.
| Mean KO ± SE | Mean WT ± SE | nKO, nWT, P | |
|---|---|---|---|
| CO (μl/min) | 19.507 ± 745 | 19.083 ± 858 | 6, 7; 0.72 |
| Δ SO2, a−v (%) | 47.0 ± 5.6 | 36.4 ± 3.3 | 9, 11; 0.13 |
| cHb (g/100 ml) | 11.9 ± 0.2 | 12.9 ± 0.2 | 7, 6; 0.006 |
| Body wt. (g) | 22.9 ± 1.2 | 25.2 ± 1.1 | 7, 7; 0.17 |
| VO2, dob (ml/min/g) | 0.064 ± 0.012 | 0.054 ± 0.008 | 6, 6; 0.49 |
CO, cardiac output from P-V loop measurements; Δ SO2, a−v, arterio-venous O2 saturation difference; cHb, blood hemoglobin concentration; VO2, dob, specific oxygen consumption of whole animals under 40 ng/g/min dobutamine infusion, calculated from the other parameters given in the table. KO and WT groups comprise both sexes. The differences in body weights that are statistically significant when sexes are separated (Figure 1), loose significance upon combining sexes, although still apparent. The VO2, dob values shown are nearly a factor of two greater than the basal oxygen consumption of mice of ca. 0.03–0.04 ml/min/g.