Fig.11.

Double staining of myelin basic protein (MBP) and (E, E)-1-fluoro-2,5-bis (3-hydroxycarbonyl-4-hydroxy) styrylbenzene (FSB) in the amyloid plaques of 5XFAD mice. MBP positive myelin aggregates were detected in cortex of 8 month (8M, left panel) old (A) and 10 month (10M, left panel) old (b) 5XFAD mice. These MBP myelin aggregates co-localized (Merge) with FSB stained amyloid plaques in the cortex of 8 month old (8M, middle upper panel) and 10 month (10M, middle lower panel) old 5XFAD mice. MBP aggregates at 10 months (10M) seemed somewhat fragmented (B). The FSB stained plaques co-localized with MBP staining in 8M (upper right panel) and 10M (lower right panel) old animals (Merge). Bar = 50 μm.