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Measured profiles for plasma glucose (A), insulin (B), and C-peptide (C) concentrations. The calculated ISR is shown in the inset of C; only the first 40 min are shown to highlight the region where insulin secretion is highest. In panel D, the total amount of insulin secreted and infused over the intervals 0–5 min and 20–25 min are shown. Values shown are the mean ± SD.
