Figure 4.

Distribution of parameter values and the relationship between the clearance for endogenously secreted insulin (CL_portal) and measures of insulin sensitivity and release. Panels A–E show the distribution of values for the various model parameters, with the y-axis showing the number of subjects in each range of parameter values. Panel F shows the relationship between FE_L and CL_P in the population. Panels G and H show the relationships between CL_P and S_I (panel G) and CL_portal and AIR_g (panel H); units for S_I are 10⁻⁴/(pmol/L)/min and units for AIR_g are pmol/L ⋅ min. Regression relationships were obtained using either linear regression (panel G) or nonlinear regression with a power function (AIR_g = β₁ ⋅ CL_portal^β2).