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. 2016 Feb 16;65(6):1741–1751. doi: 10.2337/db15-0999

Figure 1.

Figure 1

Circadian phase of DLMOff and duration of elevated melatonin levels vary by MTNR1B genotype in the in-laboratory cohort. Adjusted mean and standard error shown by rs10830963 genotype (T2D risk allele G). P value derived from multiple linear regression tests between genotype and phenotype adjusted for age, sex, and principal components of ancestry. A: Circadian phase of DLMOff (n = 95, adjusted mean [SE] in clock time, CC 07:49 [23 min], CG 09:10 [24 min], and GG 10:32 [35 min]). B: Duration of melatonin production (n = 94, adjusted means [SE] in clock time, CC 9.70 h [0.74], CG 10.38 h [1.15], and GG 11.07 h [1.21]).