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Sleep timing modifies the effect of MTNR1B variant rs10830963 on risk of T2D in MESA (n = 1,513). The effect of sleep timing on T2D risk is shown by rs10830963 genotype. The rs10830963G T2D risk allele is shown in red. Lines represent the genotype-specific linear regression of rs10830963 × 7-day actigraphy measured at bedtime (A), midpoint (B), and wake time (C) in 1,513 subjects of multiethnic ancestry, adjusted for age, sex, and BMI.
