Table 2.
MTNR1B rs10830963 association with sleep, circadian, and melatonin traits in the in-laboratory studies
| N | β | SE | P | |
|---|---|---|---|---|
| Owl/lark questionnaire, numeric score |
193 |
−0.345 |
2.389 |
0.885 |
| Bedtime, clock time |
151 |
30.36 |
19.38 |
0.119 |
| Sleep midpoint, clock time |
151 |
31.8 |
19.38 |
0.103 |
| Wake time, clock time |
151 |
33.12 |
19.5 |
0.091 |
| Calculated sleep duration, h |
151 |
0.046 |
0.033 |
0.165 |
| Phase of DLMO, clock time |
96 |
0.648 |
0.542 |
0.236 |
| Phase angle between melatonin onset and sleep midpoint, h |
93 |
0.165 |
0.338 |
0.627 |
| Midpoint of melatonin secretion, clock time |
95 |
1.014 |
0.514 |
0.052 |
| Phase of DLMOff, clock time |
95 |
1.361 |
0.55 |
0.015 |
| Phase angle between melatonin offset and sleep midpoint, h |
93 |
0.45 |
0.382 |
0.242 |
| Phase of melatonin synthesis offset, clock time |
82 |
1.047 |
0.624 |
0.097 |
| Duration of melatonin secretion, h |
94 |
0.684 |
0.314 |
0.032 |
| Plasma melatonin clearance rate, min−1 |
80 |
−0.006 |
0.007 |
0.382 |
| Plasma melatonin clearance half-life, min |
80 |
4.753 |
7.048 |
0.502 |
| Circadian melatonin amplitude, pg/mL |
95 |
0.058 |
7.258 |
0.994 |
| Circadian period of melatonin, h |
57 |
0.01 |
0.067 |
0.885 |
| Phase of circadian CBT nadir, clock time |
90 |
0.627 |
0.575 |
0.279 |
| Phase angle between CBT nadir and sleep midpoint, h |
88 |
−0.242 |
0.413 |
0.559 |
| Circadian CBT amplitude, °F |
89 |
−0.027 |
0.042 |
0.521 |
| Circadian period of CBT, h | 63 | 0.003 | 0.069 | 0.964 |
Results are from linear regression analysis in whites adjusted for age, sex, and five principal components of ancestry. Significant results are shown in boldface type, no correction was applied for multiple phenotypes. Allele frequency of rs10830963 in the in-laboratory studies was 0.32.