Table 3.
MTNR1B rs10830963 association with sleep traits in CARe study
| rs10830963G |
|||||
|---|---|---|---|---|---|
| N | Effect/OR (95%CI) | SE | P | Minimum effect detectable† | |
| Bedtime, weekday, min |
4,359 |
−0.72 |
1.50 |
0.63 |
3.93 |
| Bedtime, weekend, min |
4,346 |
−0.84 |
1.56 |
0.60 |
4.2 |
| Sleep midpoint, weekday, min |
4,329 |
−0.78 |
1.20 |
0.51 |
3.3 |
| Sleep midpoint, weekend, min |
4,321 |
−0.66 |
1.20 |
0.58 |
3.3 |
| Wake time, weekday, min |
4,344 |
−1.08 |
1.62 |
0.51 |
4.5 |
| Wake time, weekend, min |
4,347 |
−0.78 |
1.80 |
0.66 |
4.8 |
| Self-report average weekly sleep duration, h |
6,406 |
0.01 |
0.03 |
0.62 |
0.135 |
| Self-report average weekday sleep duration, h |
6,321 |
0.02 |
0.02 |
0.45 |
0.065 |
| Self-report average weekend sleep duration, h |
4,333 |
0.01 |
0.03 |
0.69 |
0.08 |
| Calculated average weekly sleep duration, h |
4,295 |
0.00 |
0.03 |
0.99 |
0.07 |
| Calculated average weekday sleep duration, h |
4,323 |
−0.01 |
0.03 |
0.85 |
0.07 |
| Calculated average weekend sleep duration, h |
4,307 |
0.01 |
0.03 |
0.83 |
0.08 |
| REM sleep percent, PSG measured |
3,021 |
0.22 |
0.19 |
0.23 |
0.53 |
| Stage 1 sleep percent, PSG measured |
3,021 |
0.18 |
0.11 |
0.08 |
0.31 |
| Stage 2 sleep percent, PSG measured |
3,021 |
0.15 |
0.35 |
0.67 |
1.045 |
| Stage 3/4 sleep percent, PSG measured |
3,021 |
-0.55 |
0.32 |
0.08 |
0.97 |
| Sleep latency, min |
6,316 |
0.99 |
0.01 |
0.38 |
1.15 |
| Objectively measured bedtime, min |
1,513 |
−2.20 |
3.54 |
0.54 |
9.7 |
| Objectively measured sleep midpoint, min |
1,513 |
−1.92 |
0.75 |
0.53 |
8.1 |
| Objectively measured wake time, min |
1,513 |
−1.64 |
3.50 |
0.64 |
9.6 |
| Frequent difficulty falling asleep |
9,846 |
1.01 (0.94–1.07) |
0.88 |
1.052 |
|
| Frequent early awakening |
9,808 |
0.98 (0.92–1.05) |
0.66 |
1.051 |
|
| Frequent daytime sleepiness |
9,977 |
0.98 (0.91–1.05) |
0.65 |
1.05 |
|
| Frequent naps |
6,457 |
1.06 (0.98–1.15) |
0.15 |
1.0875 |
|
| Frequent wake after sleep onset | 9,855 | 0.97 (0.91–1.04) | 0.43 | 1.064 | |
Results are from linear or logistic regression analyses adjusting for age, sex, BMI, and ancestry. Suggestive results are shown in boldface type. Allele frequency was 0.27.
†Minimum detectable effect at 80% power, α = 0.05. REM, rapid eye movement.