Table 4.
Interaction results of rs10830963 with sleep timing on T2D risk
| Interaction phenotype | Effect allele | Ethnicity | MAF | N | Early timing |
Late timing |
Pinteraction | |||
|---|---|---|---|---|---|---|---|---|---|---|
| CHR | SNP | OR (95% CI) | OR (95% CI) | SE | ||||||
| Bedtime |
11 |
rs10830963 |
G |
Whites |
0.26 |
619 |
1.48 (1.01–2.18) |
1.29 (0.77–2.16) |
0.1446 |
0.1907 |
| Asians |
0.42 |
167 |
2.38 (0.88–6.46) |
0.70 (0.24–2.07) |
0.2356 |
0.1170 |
||||
| Blacks |
0.08 |
370 |
1.11 (0.56–2.19) |
1.34 (0.60–3.00) |
0.1867 |
0.9468 |
||||
| Hispanics |
0.19 |
357 |
1.07 (0.57–2.04) |
1.02 (0.55–1.89) |
0.1490 |
0.2639 |
||||
| Meta-analysis |
0.22 |
1,513 |
1.38 (1.03–1.83) |
1.14 (0.81–1.60) |
0.0846 |
0.0533 |
||||
| Sleep midpoint |
11 |
rs10830963 |
G |
Whites |
0.26 |
619 |
1.80 (1.00–3.22) |
1.34 (0.79–2.29) |
0.1783 |
0.0549 |
| Asians |
0.42 |
167 |
2.45 (0.89–6.70) |
0.97 (0.37–2.49) |
0.3007 |
0.0626 |
||||
| Blacks |
0.08 |
370 |
1.07 (0.57–2.02) |
1.02 (0.55–1.89) |
0.2118 |
0.5954 |
||||
| Hispanics |
0.19 |
357 |
1.30 (0.59–2.90) |
1.05 (0.53–2.07) |
0.1668 |
0.4665 |
||||
| Meta-analysis |
0.22 |
1,513 |
1.49 (1.05–2.13) |
1.13 (0.81–1.57) |
0.0996 |
0.0180 |
||||
| Wake time |
11 |
rs10830963 |
G |
Whites |
0.26 |
619 |
1.88 (1.04–3.40) |
1.25 (0.74–2.13) |
0.1720 |
0.0320 |
| Asians |
0.42 |
167 |
2.09 (0.85–5.06) |
0.84 (0.37–2.63) |
0.2672 |
0.1616 |
||||
| Blacks |
0.08 |
370 |
1.33 (0.61–2.94) |
0.94 (0.47–1.87) |
0.1808 |
0.3368 |
||||
| Hispanics |
0.19 |
357 |
0.84 (0.44–1.60) |
1.26 (0.67–2.37) |
0.1490 |
0.8488 |
||||
| Meta-analysis | 0.22 | 1,513 | 1.32 (0.95–1.84) | 1.13 (0.82–1.57) | 0.0900 | 0.0290 |
Results are from logistic regression with an interaction term. Model is adjusted for age, sex, and BMI. Wake time was measured by actigraphy across a minimum of 3 days. CHR, chromosome; MAF, minor G allele frequency. Odds of T2D are shown stratified by the median bedtime, midpoint, and wake time into “early” and “late.” Significant results (P < 0.05) are shown in boldface type.