Figure 2.

Inhibition of DYRK and CLK kinase families by 5-IT. A: Comparison of the effects of 6-day treatment with 5-IT and the structurally unrelated adenosine kinase inhibitor ABT-702. The percent of β-cells positive for EdU was measured and calculated. Data represent the mean ± SD of four independent wells and nine fields of view per well. **P < 0.01, compared with DMSO treatment, two-tailed Student t test. B: Kinome profiling of 253 human kinases. Tested kinases are indicated by closed circles, kinases inhibited by 5-IT are indicated in red, and the kinase inhibited by ABT-702 is indicated in green. C: Dose-dependent inhibition of indicated DYRK and CLK by 5-IT.