Figure 8.

5-IT treatment did not increase cell proliferation in other tissues. Representative images (A) and quantification (B) of nuclei BrdU⁺ in indicated tissues. Insets show BrdU⁺ proliferating cells. For each mouse, a minimum of 3,000 cells were counted in sections from liver and muscle and 1,000–2,000 cells were counted in sections from visceral (Visc.) and subcutaneous (Sc.) adipose tissue. Representative experiment from n = 4. Error bars indicate ±SEM. HI, human islet; HI Tx, vehicle treated; HI Tx + 5IT, 5-IT treated.