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. 2016 Feb 9;65(6):1511–1520. doi: 10.2337/db15-1552

Figure 3.

Figure 3

Deletion of neuronal insulin receptor signaling reduces TG secretion, while the targeted knockout of insulin receptors restricted to the periphery increases TG secretion rates. A: Experimental protocol. B: Body weights of Nirko mice and littermate controls (n ≥ 9/group). C: Blood glucose levels of Nirko and littermate controls at baseline of the tyloxapol infusion experiment (n ≥ 9/group). D: Plasma TG levels at baseline (0) and 1 and 2 h after a tyloxapol injection in Nirko vs. littermate control mice (n ≥ 9/group). E–G: VLDL secretion rates as assessed after tyloxapol infusion experiments in Nirko, IR∆PER (n = 5/group), and IR∆WB (n ≥ 6/group) mice vs. their respective controls. All error bars are SEM. *P < 0.05 vs. controls. hrs, hours; N.S., not significant.