Table 9.2.

Endometrial carcinoma miRNAs, their expression level, proposed function and transcriptional targets

miRNA	Cell/tissue type	↑/↓	Function	Proposed target	Validationa	References
miR-200a/b/c	HEC-1A, Ishikawa cell lines	↑	Proliferation	NAb	Yes	Lee et al. (2011)
miR-141, miR-429
miR-200c	HEC-1A, Ishikawa cell lines	↑	Proliferation	BRD7	Yes	Park et al. (2012)
miR-9, miR-27,	Endometrial carcinoma tissue, Ishikawa cells	↑	NDc	FOXO1 (decreased)	ND	Myatt et al. (2010)
miR-96, miR-153,
miR-182, miR-183,
miR-186	HEC-1B cells		Proliferation	FOXO1	Yes	Myatt et al. (2010)
miR-7, miR-149,	Endometrial carcinoma tissue	↑	ND	NA	ND	Myatt and Lam (2007)
miR-449b, miR-204
miR-204	HEC-1A cell line		Migration, invasion	FOXC1	Yes	Myatt and Lam (2007)
miR-125b	Type II endometrial carcinoma cells	↑	Proliferation, invasion (in vitro and in vivo)	TP53INP1	Yes	Jiang et al. (2011)

^aTarget validation was performed by 3″ UTR reporter construct assays and/or, miRNA transfection and Western analysis

^bNA = function or proposed target was not assessed in the cited study

^cND = not determined