Appendix A.
Chromosome | Nearest Gene | GWAS SNPa | HRS SNP | Imputation Quality R2 | R2 with GWAS SNP | Allele |
GWAS Betac | HRS Beta | Effect Allele Frequencyd | |
---|---|---|---|---|---|---|---|---|---|---|
Effectc | Other | |||||||||
1 | SEC16B | rs543874 | rs543874 | 1.00 | 1.00 | G | A | .22 | .08 | .20 |
1 | TNNI3K | rs1514175 | rs1514175 | 1.00 | 1.00 | A | G | .07 | .09 | .47 |
1 | PTBP2 | rs1555543 | rs10489741b | 1.00 | 1.00 | C | A | .06 | .09 | .57 |
1 | NEGR1 | rs2815752 | rs2815752 | 1.00 | 1.00 | A | G | .13 | .09 | .62 |
2 | LRP1B | rs2890652 | rs2890652b | 1.00 | 1.00 | C | T | .09 | .05 | .19 |
2 | FANCL | rs887912 | rs887912b | 1.00 | 1.00 | T | C | .10 | .06 | .24 |
2 | RBJ | rs713586 | rs713586b | 1.00 | 1.00 | C | T | .14 | .20 | .52 |
2 | TMEM18 | rs2867125 | rs2867125 | 1.00 | 1.00 | C | T | .31 | .27 | .84 |
3 | CADM2 | rs13078807 | rs13078807 | 1.00 | 1.00 | G | A | .10 | −.04 | .17 |
3 | ETV5 | rs9816226 | rs9816226b | .99 | 1.00 | T | A | .14 | .21 | .82 |
4 | SLC39A8 | rs13107325 | rs13107325 | 1.00 | 1.00 | T | C | .19 | .36 | .06 |
4 | GNPDA2 | rs10938397 | rs10938397 | 1.00 | 1.00 | G | A | .18 | .10 | .40 |
5 | ZNF608 | rs4836133 | rs4836133b | 1.00 | 1.00 | A | C | .07 | .12 | .58 |
5 | FLJ35779 | rs2112347 | rs2112347b | 1.00 | 1.00 | T | G | .10 | .16 | .62 |
6 | TFAP2B | rs987237 | rs987237 | 1.00 | 1.00 | G | A | .13 | .04 | .18 |
6 | NUDT3 | rs206936 | rs206936 | 1.00 | 1.00 | G | A | .06 | .03 | .27 |
9 | LRRN6C | rs10968576 | rs10968576 | 1.00 | 1.00 | G | A | .11 | .26 | .28 |
11 | MTCH2 | rs3817334 | rs3817334b | 1.00 | 1.00 | T | C | .06 | .05 | .39 |
11 | RPL27A | rs4929949 | rs4929949b | 1.00 | 1.00 | C | T | .06 | −.03 | .49 |
11 | BDNF | rs10767664 | rs10767664b | 1.00 | 1.00 | A | T | .19 | .15 | .80 |
12 | FAIM2 | rs7138803 | rs7138803 | 1.00 | 1.00 | A | G | .12 | .14 | .34 |
13 | MTIF3 | rs4771122 | rs9512699b | 1.00 | .87 | G | A | .09 | .22 | .18 |
14 | PRKD1 | rs11847697 | rs10134820b | 1.00 | .74 | T | C | .17 | −.03 | .06 |
14 | NRXN3 | rs10150332 | rs10150332b | 1.00 | 1.00 | C | T | .13 | .03 | .23 |
15 | MAP2K5 | rs2241423 | rs2241423 | 1.00 | 1.00 | G | A | .13 | .21 | .72 |
16 | SH2B1 | rs7359397 | rs7359397b | 1.00 | 1.00 | T | C | .15 | .18 | .35 |
16 | FTO | rs1558902 | rs1558902b | 1.00 | 1.00 | A | T | .39 | .30 | .35 |
16 | GPRC5B | rs12444979 | rs12444979 | 1.00 | 1.00 | C | T | .17 | .25 | .87 |
18 | MC4R | rs571312 | rs571312 | 1.00 | 1.00 | A | C | .23 | .29 | .24 |
19 | KCTD15 | rs29941 | rs29941b | 1.00 | 1.00 | G | A | .06 | .09 | .70 |
19 | TMEM160 | rs3810291 | rs3810291 | 1.00 | 1.00 | A | G | .09 | .13 | .59 |
19 | QPCTL | rs2287019 | rs2287019 | 1.00 | 1.00 | C | T | .15 | .22 | .89 |
Note:
rs ids of BMI-related SNPs in Speliotes et al. (2010).
Imputed SNPs
Effect size in kg/m2 of BMI obtained from Speliotes et al. (2010).
Effect allele frequency in HRS.