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CREER yields highly efficient levels of mHtt excisional recombination in Q97CRE mice. In contrast to striatal Q97 specimens, RT-PCR amplicons using primers that selectively detect the presence of mutant exon 1 of the Htt cDNA (Top) and Western blot analysis probed with the mAb 2166 anti-Htt antibody (∼350 kDa, Bottom) show no discernible bands in control and Q97CRE striatal specimens (nper strain = 3).
