Fig. 3.

Q97^CRE mice have analogous, although less severe, motor deficits compared with Q97 mice. Behavioral examinations were performed at 3 and 9 mo of age in a single cohort of female mice from each experimental group (n = 10, n = 9, and n = 12 for Q97^CRE, Q97, and CTL mice, respectively). Compared with CTL mice, both Q97^CRE and Q97 mice displayed deficits in limb grip strength (paw grip endurance hanging wire test) at 9 mo of age (A) and a higher number of slips in the balance beam test at 3 and 9 mo of age (B). (C and D) Consistently, repeated rotarod tests at 3 and 9 mo of age also revealed significant deficits in motor coordination in Q97^CRE mice. Individual values represent the mean ± SEM. P values (*) depicted at the top or next to each experimental group in A and B represent the statistical comparison with corresponding age-matched controls.