Fig. 5.
GD3S regulates sphere formation through activation of c-Met signaling. (A) Western blot analysis of p-c-Met and c-Met expression in DBTRG parental cells, neurospheres, and both of them transfected with KD control and GD3S KD plasmid. (B) Expression of p-c-Met and c-Met in DBTRG GD3S O/E cells treated with or without SU11274. (C) SU11274 treatment in DBTRG O/E control and DBTRG GD3S O/E cells was used for sphere formation assay. The mean ± SD for each group (n = 10) is shown. The P value was obtained by one-way ANOVA. Ctrl, control; SU, SU11274. *P < 0.05; **P < 0.01.