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TPC2 regulates melanosome luminal pH. (A) Wild-type or CRISPR TPC2-KO MNT-1 cells expressing MELOPS and tyrosinase-iRFP were analyzed by confocal fluorescence microscopy. In a rescue experiment performed in parallel, TPC2-KO MNT-1 cells expressing MELOPS and TPC2-iRFP were also analyzed. (Scale bar, 5 µm.) (B) The average MELOPS fluorescence intensity was determined for all treatments (WT+Tyr = 30 cells; TPC2-KO+Tyr = 25 cells; TPC2-KO+TPC2 = 21 cells).
