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TPC2 regulates melanosomal pH in primary human melanocytes. (A and B) The average fluorescence intensity of MELOPS was determined for primary human melanocytes subjected to either control siRNA (n = 38 cells) or TPC2 siRNA knockdown (n = 44 cells). (C and D) The average fluorescence intensity of MELOPS was determined for primary human melanocytes overexpressing LAMP2-GFP as a control (n = 47 cells) or TPC2-GFP (n = 50 cells).
