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TPC2 inhibitors alkalize the melanosomal lumen and increase melanin content in MNT-1 cells. (A) The average fluorescence intensity of MELOPS was determined for MNT-1 cells overexpressing LAMP2-GFP, as a control (n = 31 cells), or for TPC2-GFP, and treated for 1 h with vehicle (DMSO; n = 28 cells) or the TPC2 inhibitors Ned19 (100 µM; n = 36 cells) and tetrandrine (2 µM; n = 36 cells). (B) Melanin content was determined for MNT-1 cells treated with DMSO or Ned19 (100 µM) for 6 d.
