Figure 4.

MTA-1 and nm23-H1 RNA expression levels in the different groups. The Bonferroni test was used for multiple comparisons. In the Per2 overexpression group, the MTA-1 expression was significantly decreased, demonstrating an expression level of ~1/10 of the PBS control group. However, the expression level of nm23-H1 was ~12 times greater than the PBS control group. Data are presented as the mean ± standard deviation. ^*P<0.001 vs. PBS control and empty plasmid. MTA-1, metastasis-associated gene 1; nm23-H1, non-metastasis protein 23-H1; Per2, Period2; PBS, phosphate-buffered saline.