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Effects of ALD on the distribution of p53 (magnification, ×400). The level of p53 expression was markedly higher in renal cortical sections from ALD-infused rats, as compared with those from the control group rats, as determined by immunohistochemical analyses. Furthermore, the p53 protein was predominantly expressed in the renal cortex, whereas negligible p53 protein expression was observed in the normal tissue samples. ALD, aldosterone.
