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. 2016 Apr 21;13(6):5102–5108. doi: 10.3892/mmr.2016.5156

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Copyright: © Shi et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of ALD and p53 siRNA on p53 protein expression levels in rat mesangial cells. (a) Con; (b) siRNA-p53; (c) siRNA-con; (d) ALD; (e) ALD + siRNA-p53; (f) ALD + siRNA-con. At the end of the incubation period, the p53 protein level was upregulated in the ALD group when compared with the con group (1.00±0.05 vs. 1.83±0.24; P<0.05); whereas the p53 protein levels were significantly decreased by knockdown of p53 with siRNA (0.89±0.03; P<0.05). Values are presented as means ± standard deviation from three independent experiments. ^*P<0.05 vs. con; ^#P<0.05 vs. ALD. ALD, aldosterone; siRNA, small interfering RNA; con, control.