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. 2016 Apr 14;13(6):4627–4635. doi: 10.3892/mmr.2016.5133

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Copyright: © Jia et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Immunohistochemical detection of SREBP-2, Pcsk9 and LDL-R expression in the liver tissue. Tissue from the CON, HLP and TAN groups was collected and stained with antibodies against SREBP-2, Pcsk9 and LDL-R. (A) SREBP-2 protein expression in liver tissue. (B) Pcsk9 protein expression in liver tissue. Data are presented as the mean ± standard deviation. ^**P<0.01. SREBP-2, sterol regulatory element-binding protein 2; Pcsk9, proprotein convertase subtilisin/kexin type 9; LDL-R, low-density lipoprotein receptor; CON, control; HLP, high lipid diet-fed rats; TAN, Tanshinone IIA treatment of high lipid diet-fed rats; IOD, integrated optical density. (C) LDL-R protein expression in liver tissue. Data are presented as the mean ± standard deviation. ^**P<0.01. LDL-R, low-density lipoprotein receptor; CON, control; HLP, high lipid diet-fed rats; TAN, Tanshinone IIA treatment of high lipid diet-fed rats; IOD, integrated optical density.

Immunohistochemical detection of SREBP-2, Pcsk9 and LDL-R expression in the liver tissue. Tissue from the CON, HLP and TAN groups was collected and stained with antibodies against SREBP-2, Pcsk9 and LDL-R. (A) SREBP-2 protein expression in liver tissue. (B) Pcsk9 protein expression in liver tissue. Data are presented as the mean ± standard deviation. ^**P<0.01. SREBP-2, sterol regulatory element-binding protein 2; Pcsk9, proprotein convertase subtilisin/kexin type 9; LDL-R, low-density lipoprotein receptor; CON, control; HLP, high lipid diet-fed rats; TAN, Tanshinone IIA treatment of high lipid diet-fed rats; IOD, integrated optical density. (C) LDL-R protein expression in liver tissue. Data are presented as the mean ± standard deviation. ^**P<0.01. LDL-R, low-density lipoprotein receptor; CON, control; HLP, high lipid diet-fed rats; TAN, Tanshinone IIA treatment of high lipid diet-fed rats; IOD, integrated optical density.