Extended Data Figure 3. Comparison of Cdc20 and Cdh1 association to the APC/C.

a, The catalytic module (Apc2-Apc11) of the APC/C^Cdc20-Hsl1 complex is flexible and almost no density accounting for Apc11 (pink, modelled based on the structure of APC/C^Cdh1-Emi1, PDB 4UI9)²³ could be observed. b, The WD40 domain of Cdc20 (purple) occupies a similar position as Cdh1^WD40 (grey), but it is displaced from the APC/C by as much as 10 Å. c, d, EM density for Cdc20^{C box} allowed for ab initio model building and the C-box interaction with Apc8B (cyan) is well conserved between the two coactivators. e, Both Cdc20^IR and Cdh1^IR associates with Apc3A (orange), although the EM density for Cdc20^IR is much weaker (not shown) and the C-terminal α-helix in Cdh1^IR is absent.