Table 5.
Prevalence of Overlapping Use of the 5 Antimicrobial Drugs Associated With Hypoglycemia Among Glipizide or Glyburide Users in 2007 and 2009a
| Antimicrobial Drug | Glypizide and Glyburide Users, No. (%) | |
|---|---|---|
| 2007 (n = 136 160) |
2009 (n = 140 174) |
|
| Ciprofloxacin | 16 661 (12.24) | 18 149 (12.95) |
| Clarithromycin | 1942 (1.43) | 1757 (1.25) |
| Levofloxacin | 14 186 (10.42) | 13 458 (9.60) |
| Metronidazole | 2967 (2.18) | 3305 (2.37) |
| Sulfamethoxazole-trimethoprim | 13 017 (9.56) | 14 347 (10.24) |
| Any of the above | 38 048 (27.94) | 39 631 (28.27) |
a
The denominator was beneficiaries who had complete Part D enrollment and at least 1 glipizide or glyburide prescription in a given year. The numerator was beneficiaries who filled a prescription for 1 of the antimicrobials, and the supply of the antimicrobial prescription overlapped the supply of the glipizide or glyburide by at least 1 day. The total number of prescriptions for 1 of the 5 interacting antimicrobials in patients taking a sulfonylurea was 66 875 in 2007 and 69 537 in 2009.