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. Author manuscript; available in PMC: 2017 May 15.
Published in final edited form as: Brain Res. 2016 Mar 17;1639:200–213. doi: 10.1016/j.brainres.2016.01.058

Figure 3.

Figure 3

A) Supraphysiologic 17β-estradiol (E2) treatment at time of reperfusion resulted in a significantly smaller total lesion volume compared to placebo (P) treated animals (27% vs. 4%, *p = 0.007, Mann-Whitney U test). The dot plot of lesion volumes for individual animals reveals non-normal distribution among the E2 treatment group, which is comprised of high and low responding animals. B) Striatal lesion volume was significantly smaller with E2 treatment (46% vs. 31%, #p = 0.006, unpaired t-test). C) E2 treatment also significantly decreased cortical lesion volume (49% vs. 0%, ^p = 0.003 Gaussian approximation, Mann-Whitney U test). Median values and 25th-75th percentile are represented in A and C, with mean ± sd for B.