Table 3.
Summary of MRI data from a subset of E2 and P treated rats 4 weeks after tMCAO (n = 4 per group each).
| MRI Lesion and Perfusion Data | Placebo, n=4 | Estradiol, n=4 | p-value | |
|---|---|---|---|---|
| Lesion Volume (mm3) | 136 ± 15 | 58 ± 60 | 0.046* | |
| Lesion Volume (% of brain volume) | 14 ± 0.01 | 6 ± 0.06 | 0.041* | |
| Lesion Volume (% contra) | 47 ± 3 | 33 ± 24 | 0.336^ | |
| Cyst (% of lesion) | 53 ± 6 | 14 ± 16 | 0.004* | |
| Total Lesion | CBF | 0.82 ± 0.09 | 1.06 ± 0.11 | 0.014* |
| CBV | 0.85 ± 0.08 | 1.01 ± 0.14 | 0.092 | |
| Ktrans (mean) | 0.09 ± 0.09 | 0.07 ± 0.06 | 0.704 | |
| Ktrans (%>0.1) | 13.3 ± 11 | 17.5 ± 13 | 0.646 | |
| Lesion w/o Cyst | CBF | 1.18 ± 0.14 | 1.12 ± 0.09 | 0.547 |
| CBV | 1.24 ± 0.11 | 1.09 ± 0.22 | 0.277 | |
| Ktrans (mean) | 0.20 ± 0.24 | 0.09 ± 0.08 | 0.389 | |
| Ktrans (%>0.1) | 22.4 ± 18 | 19.3 ± 18 | 0.806 | |
| Cyst only | CBF | 0.51 ± 0.08 | 0.71 ± 0.10 | 0.045* |
| CBV | 0.45 ± 0.07 | 0.64 ± 0.07 | 0.037* | |
| Ktrans (mean) | 0.03 ± 0.01 | 0.04 ± 0.001 | 0.213 | |
| Ktrans (%>0.1) | 6.4 ± 6 | 8.9 ± 7 | 0.671 | |
| Contralateral | Ktrans (mean) | 0.04 ± 0.01 | 0.04 ± 0.02 | 0.491 |
| Ktrans (%>0.1) | 5.6 ± 2 | 4.9 ± 2 | 0.617 |
All data is presented as mean ± sd and analyzed with unpaired t-test
^
denotes unpaired t-test with Welch's correction
*
denotes significance by a p-value < 0.05.
CBF and CBV measures are represented as relative to the contralateral hemisphere. Ktrans is shown in terms of both its mean, and the % of pixels within the ROI above the threshold of 0.1.