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(A) Crystal structure of the CAR LBD. Ligand-binding pocket residues are highlighted in magenta. The cavity of the binding pocket is represented as a space-filled model. The CAR pocket has a calculated volume of ~700 Å3. (B) Chemical properties of the residues that surround the CAR ligand-binding pocket. Amino acids are colored to represent the chemical property: orange (hydrophobic); green (polar); blue (basic); red (acidic); yellow (cysteine); and white (glycine).
