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. Author manuscript; available in PMC: 2016 May 24.
Published in final edited form as: J Neurochem. 2010 Oct 26;115(5):1172–1182. doi: 10.1111/j.1471-4159.2010.07013.x

Fig. 5.

Fig. 5

mtDNA damage increased in a time-dependent manner during Li-Pilo-induced epileptogenesis. mtDNA lesion frequency determined using QPCR specific to a 13.4 kb mitochondrial fragment in the (a,a1) hippocampus and (c) piriform cortex during Li-Pilo-induced epileptogenesis in rats that received diazepam to attenuate SE. Panel (a1) is a representative agarose gel derived from QPCR analysis of hippocampal tissue after Lil-Pilo treatment. Lane 1, CON; lane 2, 24 h; lane 3, 48 h; lane 4, 96 h; lane 5, 7 days; lane 6, 21 days; lane 7, 3 months. mtDNA lesion frequency at 48 h from rats that did not receive diazepam are shown in the (b) hippocampus and (d) piriform cortex. Note that lesion frequency increased significantly at 48 h when motor seizures were allowed to continue during SE without diazepam treatment. Bars represent mean ± SEM, n = 5–10. *p < 0.05, **p < 0.01, ***p < 0.001, one-way anova.