Table 3.

Effects of Maternal Helminth Infections on Achievement of a Designated Protective Antibody Threshold Following Infant Vaccination

Antigen	OR (95% CI)	P Values			Adjusted OR (95% CI)	P Values
		2 Sided	Adjusted for Helminth Detection in Child at Age 13 mo	Corrected by Holm Method		Adjusted	Adjusted for Helminth Detection in Child at Age 13 mo	Corrected by Holm Method
Primary end point
Rotavirus	1.3 (1.06–1.59)	.0111	.0315	.0111	1.23 (.97–1.55)	.0901	.1399	.0901
OPV3	1.39 (1.14–1.7)	.0011	.2084	.0022	1.39 (1.1–1.75)	.0059	.7609	.0117
Secondary end point
Diphtheria toxoid	0.5 (1.27–.9)	.0192	.6624	.0959	0.47 (.25–.9)	.0220	.9061	.1318
Tetanus toxoid	0.74 (.46–1.18)	.2225	.0849	.5906	0.85 (.48–1.50)	.5745	.0679	1.0000
B. pertussis	0.86 (.69–1.06)	.1589	.0046	.5906	0.96 (.75–1.22)	.7323	.0197	1.0000
Measles virus	0.67 (.54–.84)	.0003	.4734	.0018	0.91 (.66–1.24)	.5300	.3421	1.0000
Rubella virus	1.22 (.72–2.1)	.5246	.8427	.5906	1.88 (.99–3.58)	.0548	.9671	.2738
Hib	0.7 (.44–1.12)	.1476	.1256	.5906	0.71 (.42–1.19)	.1904	.2094	.7615

A generalized additive logistic model was adjusted for calendar time, sex, child's age and helminth infection status at the 13-month evaluation, socioeconomic status, mother's antiparasite treatment, mother's education level, mother's ethnicity, urban versus rural residence, and overcrowding of home. In addition, for the tetanus toxoid response only, adjustments were made for the number of doses of tetanus toxoid received by the mother during pregnancy. The Holm method was used to adjust for multiple comparisons separately for primary and secondary end points.

Abbreviations: B. pertussis, Bordetella pertussis; CI, confidence interval; Hib, Haemophilus influenzae b; OPV3, poliovirus serotype 3 component of oral polio vaccine; OR, odds ratio.