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. 2016 May 24;11(5):e0155743. doi: 10.1371/journal.pone.0155743

Fig 6. Model prediction of Wnt-pathway activation upon WNT addition with AXIN2 feedback.

Fig 6

β-catenin (referred to by its official gene name CTNNB1 in the figure) token levels predicted by our model with arc weight from t11 to AXIN varied from 0 (no feedback; solid lines) to 0.15 (high feedback, dashed lines), and initial WNT token levels at 3, 4 and 5 (top, middle and bottom panels, respectively). We observed three spectra of β-catenin stabilizations depending on initial WNT levels. The highest β-catenin stabilizations correspond to simulations without AXIN2 feedback (solid lines), whereas with high AXIN2 feedback the β-catenin stabilization was attenuated (dashed lines).